abstract：:Osteosarcoma (OS) is the most common type of primary bone tumor. Currently, there are limited treatment options for metastatic OS. Alpha-ketoglutarate (AKG), i.e., a multifunctional intermediate of the Krebs cycle, is one of the central metabolic regulators of tumor fate and plays an important role in cancerogenesis a...

journal_title：International journal of molecular sciences

authors： Kaławaj K,Sławińska-Brych A,Mizerska-Kowalska M,Żurek A,Bojarska-Junak A,Kandefer-Szerszeń M,Zdzisińska B

更新日期：2020-12-10 00:00:00

abstract：:Mechanotransduction is a physiological process in which external mechanical stimulations are perceived, interpreted, and translated by cells into biochemical signals. Mechanical stimulations exerted by extracellular matrix stiffness and cell-cell contacts are continuously applied to living cells, thus representing a k...

journal_title：International journal of molecular sciences

authors： Urciuoli E,Peruzzi B

更新日期：2020-12-10 00:00:00

abstract：:Stem cells for regenerative medicine purposes offer therapeutic benefits, but disadvantages are still ill defined. The benefit of stem cells may be attributed to their secretion of growth factors (GFs), cytokines (CKs), and extracellular vesicles (EVs), including exosomes. We present a novel cell-free stem cell-derive...

journal_title：International journal of molecular sciences

authors： Gupta A,Cady C,Fauser AM,Rodriguez HC,Mistovich RJ,Potty AGR,Maffulli N

更新日期：2020-12-09 00:00:00

abstract：:Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is present in the kidneys, mainly in the arterial endothelium and smooth muscle cells, as well as in the capillary endothelium, and might be considered...

journal_title：International journal of molecular sciences

authors： Przybyciński J,Dziedziejko V,Puchałowicz K,Domański L,Pawlik A

更新日期：2020-12-09 00:00:00

abstract：:Defensins are small and rather ubiquitous cysteine-rich anti-microbial peptides. These proteins may act against pathogenic microorganisms either directly (by binding and disrupting membranes) or indirectly (as signaling molecules that participate in the organization of the cellular defense). Even though defensins are ...

journal_title：International journal of molecular sciences

authors： Nikoloudakis N,Pappi P,Markakis EA,Charova SN,Fanourakis D,Paschalidis K,Delis C,Tzortzakakis EA,Tsaniklidis G

更新日期：2020-12-09 00:00:00

abstract：:Carotid atherosclerotic plaque rupture can lead to cerebrovascular accident (CVA). By comparing RNA-Seq data from vascular smooth muscle cells (VSMC) extracted from carotid atheroma surgically excised from a group of asymptomatic and symptomatic subjects, we identified more than 700 genomic variants associated with sy...

journal_title：International journal of molecular sciences

authors： Alloza I,Salegi A,Mena J,Navarro RT,Martin C,Aspichueta P,Salazar LM,Carpio JU,Cagigal PD,Vega R,Triviño JC,Freijo MDM,Vandenbroeck K

更新日期：2020-12-09 00:00:00

abstract：:There is a growing body of evidence showing the importance of physical activity against acute ischemic events in various organs. Ischemia/reperfusion injury (I/R) is characterized by tissue damage as a result of restriction and subsequent restoration of blood supply to an organ. Oxidative stress due to increased react...

journal_title：International journal of molecular sciences

authors： Szabó MR,Pipicz M,Csont T,Csonka C

更新日期：2020-12-09 00:00:00

abstract：:Pterostilbene (PTE) is a natural sterbenoid contained in blueberries that has an antioxidant effect. In contrast, PTE also generates oxidative stress in cancer cells and provides an antitumor effect. Here, we examined the potential mechanism of this contrasting effect of PTE using three gastrointestinal cancer cell li...

journal_title：International journal of molecular sciences

authors： Mori S,Kishi S,Honoki K,Fujiwara-Tani R,Moriguchi T,Sasaki T,Fujii K,Tsukamoto S,Fujii H,Kido A,Tanaka Y,Luo Y,Kuniyasu H

更新日期：2020-12-08 00:00:00

abstract：:Primitive erythrocytes are the first hematopoietic cells observed during ontogeny and are produced specifically in the yolk sac. Primitive erythrocytes express distinct hemoglobins compared with adult erythrocytes and circulate in the blood in the nucleated form. Hematopoietic stem cells produce adult-type (so-called ...

journal_title：International journal of molecular sciences

authors： Yamane T

更新日期：2020-12-08 00:00:00

abstract：:People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal hyperexcitability even in the early phases of the disease. Such aberrant activity subsequently leads to downstream accumulation of toxi...

journal_title：International journal of molecular sciences

authors： Toniolo S,Sen A,Husain M

更新日期：2020-12-07 00:00:00

abstract：:Fragile X syndrome (FXS) is a leading genetic disorder of intellectual disability caused by the loss of the functional fragile X mental retardation protein (FMRP). To date, there is no efficacious mechanism-based medication for FXS. With regard to potential disease mechanisms in FXS, it is widely accepted that the lac...

journal_title：International journal of molecular sciences

authors： Ding Q,Zhang F,Feng Y,Wang H

更新日期：2020-12-07 00:00:00

abstract：:Inorganic phosphate (Pi) is an essential nutrient for the maintenance of cells. In healthy mammals, extracellular Pi is maintained within a narrow concentration range of 0.70 to 1.55 mM. Mammalian cells depend on Na+/Pi cotransporters for Pi absorption, which have been well studied. However, a new type of sodium-indep...

journal_title：International journal of molecular sciences

authors： Lacerda-Abreu MA,Russo-Abrahão T,Meyer-Fernandes JR

更新日期：2020-12-06 00:00:00

abstract：:The micronutrients iron (Fe) and zinc (Zn) are not only essential for plant survival and proliferation but are crucial for human health. Increasing Fe and Zn levels in edible parts of plants, known as biofortification, is seen a sustainable approach to alleviate micronutrient deficiency in humans. Wheat, as one of the...

journal_title：International journal of molecular sciences

authors： Tong J,Sun M,Wang Y,Zhang Y,Rasheed A,Li M,Xia X,He Z,Hao Y

更新日期：2020-12-05 00:00:00

abstract：:Acute or chronic administration of guanosine (GUO) induces anxiolytic-like effects, for which the adenosine (ADO) system involvement has been postulated yet without a direct experimental evidence. Thus, we aimed to investigate whether adenosine receptors (ARs) are involved in the GUO-mediated anxiolytic-like effect, e...

journal_title：International journal of molecular sciences

authors： Frinchi M,Verdi V,Plescia F,Ciruela F,Grillo M,Garozzo R,Condorelli DF,Di Iorio P,Caciagli F,Ciccarelli R,Belluardo N,Di Liberto V,Mudò G

更新日期：2020-12-05 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a highly potent sphingolipid metabolite, which controls numerous physiological and pathological process via its extracellular and intracellular functions. The breast is mainly composed of epithelial cells (mammary gland) and adipocytes (stroma). Adipocytes play an important role in reg...

journal_title：International journal of molecular sciences

authors： Wu X,Sakharkar MK,Wabitsch M,Yang J

更新日期：2020-12-05 00:00:00

abstract：:Antibiotic-loaded bone graft substitutes are attractive clinical options and have been used for years either for prophylaxis or therapy for periprosthetic and fracture-related infections. Calcium sulfate and hydroxyapatite can be combined in an injectable and moldable bone graft substitute that provides dead space man...

journal_title：International journal of molecular sciences

authors： Bidossi A,Bottagisio M,Logoluso N,De Vecchi E

更新日期：2020-12-04 00:00:00

abstract：:Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number of ways, including post-translational modifications. Several studies indicate that receptor and non-receptor tyrosine kinases regulate...

journal_title：International journal of molecular sciences

authors： Vega-Rubín-de-Celis S,Kinch L,Peña-Llopis S

更新日期：2020-12-03 00:00:00

abstract：:Arterial wall remodeling underlies increased pulmonary vascular resistance and right heart failure in pulmonary arterial hypertension (PAH). None of the established vasodilator drug therapies for PAH prevents or reverse established arterial wall thickening, stiffening, and hypercontractility. Therefore, new approaches...

journal_title：International journal of molecular sciences

authors： Gerthoffer W

更新日期：2020-12-03 00:00:00

abstract：:The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly understood. It is now universally accepted that glycan expression pat...

journal_title：International journal of molecular sciences

authors： Gilgunn S,Murphy K,Stöckmann H,Conroy PJ,Murphy TB,Watson RW,O'Kennedy RJ,Rudd PM,Saldova R

更新日期：2020-12-03 00:00:00

abstract：:The ageing of human populations has become a problem throughout the world. In this context, increasing the healthy lifespan of individuals has become an important target for medical research and governments. Cardiac disease remains the leading cause of morbidity and mortality in ageing populations and results in signi...

journal_title：International journal of molecular sciences

authors： Yeh CH,Chou YJ,Kao CH,Tsai TF

更新日期：2020-12-03 00:00:00

abstract：:The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinas...

journal_title：International journal of molecular sciences

authors： Daams R,Massoumi R

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Autologous fat transfer in the form of lipoaspirates for the reconstruction of the breast after breast cancer surgery is a commonly used procedure in plastic surgery. However, concerns regarding the oncologic risk of nutrient-rich fat tissue are widely debated. Previous studies have primarily focused on stud...

journal_title：International journal of molecular sciences

authors： Ejaz A,Yang KS,Venkatesh KP,Chinnapaka S,Kokai LE,Rubin JP

更新日期：2020-12-01 00:00:00

abstract：:Abnormal uterine function affects conception rate and embryo development, thereby leading to poor fertility and reproduction failure. Exosomes are a nanosized subclass of extracellular vesicles (EV) that have important functions as intercellular communicators. They contain and carry transferable bioactive substances i...

journal_title：International journal of molecular sciences

authors： Abeysinghe P,Turner N,Morean Garcia I,Mosaad E,Peiris HN,Mitchell MD

更新日期：2020-11-30 00:00:00

abstract：:Astrocytomas and, in particular, their most severe form, glioblastoma, are the most aggressive primary brain tumors and those with the poorest vital prognosis. Standard treatment only slightly improves patient survival. Therefore, new therapies are needed. Very few risk factors have been clearly identified but many ep...

journal_title：International journal of molecular sciences

authors： Hirtz A,Rech F,Dubois-Pot-Schneider H,Dumond H

更新日期：2020-11-30 00:00:00

abstract：:Morquio B disease (MBD) is an autosomal recessive GLB1-gene-related lysosomal storage disease, presenting with a peculiar type of dysostosis multiplex which is also observed in GALNS-related Morquio A disease. MBD may present as pure skeletal phenotype (pure MBD) or in combination with the neuronopathic manifestations...

journal_title：International journal of molecular sciences

authors： Yuskiv N,Higaki K,Stockler-Ipsiroglu S

更新日期：2020-11-30 00:00:00

abstract：:Fibrosis is presented in various physiologic and pathologic conditions of the salivary gland. Transforming growth factor beta (TGF-β) pathway has a pivotal role in the pathogenesis of fibrosis in several organs, including the salivary glands. Among the TGF-β superfamily members, TGF-β1 and 2 are pro-fibrotic ligands, ...

journal_title：International journal of molecular sciences

authors： Zhang X,Yun JS,Han D,Yook JI,Kim HS,Cho ES

更新日期：2020-11-30 00:00:00

abstract：:Intracellular chloride levels in the brain are regulated primarily through the opposing effects of two cation-chloride co-transporters (CCCs), namely K+-Cl- co-transporter-2 (KCC2) and Na+-K+-Cl- co-transporter-1 (NKCC1). These CCCs are differentially expressed throughout the course of development, thereby determining...

journal_title：International journal of molecular sciences

authors： Andrews K,Josiah SS,Zhang J

更新日期：2020-11-30 00:00:00

abstract：:Addition of hydrogen peroxide (H2O2) is a method commonly used to trigger cellular oxidative stress. However, the doses used (often hundreds of micromolar) are disproportionally high with regard to physiological oxygen concentration (low micromolar). In this study using polarographic measurement of oxygen concentratio...

journal_title：International journal of molecular sciences

authors： Ransy C,Vaz C,Lombès A,Bouillaud F

更新日期：2020-11-30 00:00:00

abstract：:Herein, we propose newly designed and synthesized gold nanopeanuts (Au NPes) as supports for cisplatin (cPt) immobilization, dedicated to combined glioblastoma nano-chemo-radiotherapy. Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy (TEM) revealed that...

journal_title：International journal of molecular sciences

authors： Depciuch J,Miszczyk J,Maximenko A,Zielinski PM,Rawojć K,Panek A,Olko P,Parlinska-Wojtan M

更新日期：2020-11-29 00:00:00

abstract：:Fetal programming implies that the maternal diet during pregnancy affects the long-term health of offspring. Although maternal diet influences metabolic disorders and non-alcoholic fatty liver disease in offspring, the hepatic mechanisms related to metabolites are still unknown. Here, we investigated the maternal diet...

journal_title：International journal of molecular sciences

authors： Du JE,You YA,Kwon EJ,Kim SM,Lee J,Han KH,Kim YJ

更新日期：2020-11-28 00:00:00

abstract：:Bovine immunoglobulin G (bIgG) was previously shown to enhance innate immune responses to toll-like receptor (TLR) stimulation, via induction of trained immunity. In this study, we investigated whether minimally processed dairy streams with high levels of whey proteins as potential infant nutrition ingredients could a...

journal_title：International journal of molecular sciences

authors： Hellinga AH,Tsallis T,Eshuis T,Triantis V,Ulfman LH,Neerven RJJV

更新日期：2020-11-28 00:00:00

abstract：:The mitochondrial genome of the nematode Romanomermis culicivorax encodes for miniaturized hairpin-like tRNA molecules that lack D- as well as T-arms, strongly deviating from the consensus cloverleaf. The single tRNA nucleotidyltransferase of this organism is fully active on armless tRNAs, while the human counterpart ...

journal_title：International journal of molecular sciences

authors： Hennig O,Philipp S,Bonin S,Rollet K,Kolberg T,Jühling T,Betat H,Sauter C,Mörl M

更新日期：2020-11-28 00:00:00

abstract：:Engineering rubber composites have been widely used as main components in many fields including vehicle engineering and biomedical applications. However, when a rubber composite surface area is exposed to heat or sunlight and over a long-term accelerated exposure and lifecycle of test, the rubber becomes hard, thus in...

journal_title：International journal of molecular sciences

authors： Aziz SAA,Mazlan SA,Ubaidillah U,Mohamad N,Choi SB,Che Aziz MA,Johari MAF,Homma K

更新日期：2020-11-27 00:00:00

abstract：:The dysregulation of macrophage lipid metabolism drives atherosclerosis. AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics and plays essential roles regulating macrophage lipid dynamics. Here, we investigated the consequences of atherogenic lipoprotein-induced foam cell formation on down...

journal_title：International journal of molecular sciences

authors： LeBlond ND,Nunes JRC,Smith TKT,O'Dwyer C,Robichaud S,Gadde S,Côté M,Kemp BE,Ouimet M,Fullerton MD

更新日期：2020-11-27 00:00:00

abstract：:Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological processes. Even though the ubiquitin system has been implicated in several human diseases, the role of ...

journal_title：International journal of molecular sciences

authors： Mercado-Gómez M,Lopitz-Otsoa F,Azkargorta M,Serrano-Maciá M,Lachiondo-Ortega S,Goikoetxea-Usandizaga N,Rodríguez-Agudo R,Fernández-Ramos D,Bizkarguenaga M,Juan VG,Lectez B,Aloria K,Arizmendi JM,Simon J,Alonso C,Lozano JJ,

更新日期：2020-11-27 00:00:00

abstract：:Omics approaches for investigating biological systems were introduced in the mid-1990s and quickly consolidated to become a fundamental pillar of modern biology. The idea of measuring the whole complement of genes, transcripts, proteins, and metabolites has since become widespread and routinely adopted in the pursuit ...

journal_title：International journal of molecular sciences

authors： de Souza LP,Borghi M,Fernie A

更新日期：2020-11-26 00:00:00

abstract：:Despite recent progresses in its treatment, malignant cutaneous melanoma remains a cancer with very poor prognosis. Emerging evidences suggest that the receptor for advance glycation end products (RAGE) plays a key role in melanoma progression through its activation in both cancer and stromal cells. In tumors, RAGE ac...

journal_title：International journal of molecular sciences

authors： Olaoba OT,Kadasah S,Vetter SW,Leclerc E

更新日期：2020-11-26 00:00:00

abstract：:Overdose of acetaminophen (APAP), an antipyretic drug, is an important cause of liver injury. However, the mechanism in the rat model remains undetermined. We analyzed APAP-induced hepatotoxicity using rats based on M1/M2-macrophage functions in relation to damage-associated molecular patterns (DAMPs) and autophagy. L...

journal_title：International journal of molecular sciences

authors： Tsuji Y,Kuramochi M,Golbar HM,Izawa T,Kuwamura M,Yamate J

更新日期：2020-11-26 00:00:00

abstract：:With a global incidence of 1.8 million cases, colorectal cancer represents one of the most common cancers worldwide. Despite impressive improvements in treatment efficacy through cytotoxic and biological agents, the cancer-related death burden of metastatic colorectal cancer (mCRC) is still high. mCRC is not a genetic...

journal_title：International journal of molecular sciences

authors： Djanani A,Eller S,Öfner D,Troppmair J,Maglione M

更新日期：2020-11-26 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most frequently diagnosed types of dementia in the elderly. An important pathological feature in AD is the aggregation and deposition of the β-amyloid (Aβ) in extracellular plaques. Transthyretin (TTR) can cleave Aβ, resulting in the formation of short peptides with less activity...

journal_title：International journal of molecular sciences

authors： Zaręba N,Kepinska M

更新日期：2020-11-26 00:00:00